| Primary Identifier | MGI:1917542 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 70292 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable SH2 domain binding activity and SH3 domain binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in actin filament and focal adhesion. Predicted to be active in cytosol. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and dentate gyrus subgranular zone. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human AFAP1 (actin filament associated protein 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit inability to nurse pups due to failed secretory activation, reduced milk lipid synthesis and precocious mammary gland involution. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
