| First Author | Junker K | Year | 2000 |
| Journal | J Cancer Res Clin Oncol | Volume | 126 |
| Issue | 7 | Pages | 361-8 |
| PubMed ID | 10929757 | Mgi Jnum | J:63615 |
| Mgi Id | MGI:1861294 | Doi | 10.1007/pl00008483 |
| Citation | Junker K, et al. (2000) Pathology of small-cell lung cancer. J Cancer Res Clin Oncol 126(7):361-8 |
| abstractText | The morphological differentiation between small-cell and non-small-cell lung cancer has great prognostic and therapeutic significance for the patient. Malignant lung tumors are now classified according to the new 1999 WHO/IASLC classification of lung and pleural tumors. The variant of heterogeneously differentiated 'combined small-cell carcinoma' can be distinguished from classical small-cell carcinoma, whereas the subtype of 'intermediate cell carcinoma' is no longer used. Together with 'large-cell neuroendocrine carcinomas' and typical or atypical carcinoid tumors, small-cell lung cancers are currently histogenetically categorized as neuroendocrine lung tumors. In contrast to large-cell neuroendocrine carcinoma, the immunohistochemical demonstration of neuroendocrine differentiation is not a prerequisite for the diagnosis of small-cell lung cancer. Although electron-microscopical, immunohistochemical, and molecular-biological findings have considerably increased our understanding of the pathogenesis and progression of malignant lung tumors, routine pathological-anatomical diagnostics are still decisively based on light-microscopical evaluation of tissue samples. |
