| First Author | Ajuebor MN | Year | 1999 |
| Journal | Biochem Biophys Res Commun | Volume | 255 |
| Issue | 2 | Pages | 279-82 |
| PubMed ID | 10049699 | Mgi Jnum | J:53071 |
| Mgi Id | MGI:1331256 | Doi | 10.1006/bbrc.1999.0196 |
| Citation | Ajuebor MN, et al. (1999) Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochem Biophys Res Commun 255(2):279-82 |
| abstractText | In this study we have determined the role of endogenous interleukin (IL)-10 on leucocyte recruitment and production of the CC chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) in a murine model of acute inflammation. Intraperitoneal injection of zymosan produced a dose-dependent cellular infiltration which was concomitant with MIP-1alpha release in the lavage fluids. Release of this chemokine had a functional role since treatment of mice with a specific anti-MIP-1alpha antibody reduced both neutrophil and monocyte accumulation into the peritoneal cavity. An unexpected increase in cell influx and MIP-1alpha production was measured following depletion of resident peritoneal macrophages, as achieved by a 3-day liposome treatment. A similar result was obtained when the zymosan peritonitis response was elicited in IL-10 knock-out mice. In summary we propose a functional cross talk between endogenous IL-10 and this CC chemokine during the host inflammatory response. Copyright 1999 Academic Press. |
