| First Author | Jenne D | Year | 1988 |
| Journal | J Immunol | Volume | 140 |
| Issue | 1 | Pages | 318-23 |
| PubMed ID | 3257230 | Mgi Jnum | J:15034 |
| Mgi Id | MGI:63178 | Doi | 10.4049/jimmunol.140.1.318 |
| Citation | Jenne D, et al. (1988) cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes. J Immunol 140(1):318-23 |
| abstractText | A cDNA clone corresponding to the complete amino acid sequence of a putative protease CCP2 of murine cytotoxic T lymphocytes was isolated and sequenced. The clone encodes a 248-residue long serine esterase. The deduced N-terminal amino acid sequence is identical over 40 residues to that of granzyme C, a protease of unknown function present in granules of cytotoxic lymphocytes. Analysis of the sequence of granzyme C/CCP2 reveals high homology to other granzyme proteases, i.e. granzyme A (40%) and granzyme B (67%) and to rat mast cell protease II (46%). The amino acids lining the specificity pocket are well conserved between granzyme B, C, and rat mast cell protease II, but not granzyme A, suggesting a similar general specificity of these three proteases. |
