| First Author | Hwang I | Year | 2000 |
| Journal | J Exp Med | Volume | 191 |
| Issue | 7 | Pages | 1137-48 |
| PubMed ID | 10748232 | Mgi Jnum | J:120543 |
| Mgi Id | MGI:3706746 | Doi | 10.1084/jem.191.7.1137 |
| Citation | Hwang I, et al. (2000) T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells. J Exp Med 191(7):1137-48 |
| abstractText | At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)-peptide-major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell-APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation. |
