| First Author | Vinagre T | Year | 2010 |
| Journal | Dev Cell | Volume | 18 |
| Issue | 4 | Pages | 655-61 |
| PubMed ID | 20412779 | Mgi Jnum | J:160309 |
| Mgi Id | MGI:4454218 | Doi | 10.1016/j.devcel.2010.02.011 |
| Citation | Vinagre T, et al. (2010) Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains. Dev Cell 18(4):655-61 |
| abstractText | Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation. |
