| First Author | del Amo FF | Year | 1993 |
| Journal | Genomics | Volume | 15 |
| Issue | 2 | Pages | 259-64 |
| PubMed ID | 8449489 | Mgi Jnum | J:4071 |
| Mgi Id | MGI:52572 | Doi | 10.1006/geno.1993.1055 |
| Citation | del Amo FF, et al. (1993) Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics 15(2):259-64 |
| abstractText | The Notch gene of Drosophila encodes a large transmembrane protein involved in cell-cell interactions and cell fate decisions in the Drosophila embryo. We report here the isolation of cDNA clones encompassing the full-length coding sequence of Notch-1, a mouse homolog of Drosophila Notch. The predicted amino acid sequence of the Notch-1 protein retains all of the conserved amino acid motifs of Notch and the other vertebrate Notch homologs. The cDNA sequence predicts a 2531-amino-acid protein containing a signal peptide, 36 epidermal growth factor-like repeats, 3 Notch/lin-12 repeats, a transmembrane domain, and 6 cdc10/ankyrin repeats. The Notch-1 gene was localized to the proximal portion of mouse chromosome 2 by mapping with an interspecific backcross panel. |
