| First Author | Henning D | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 283 |
| Issue | 2 | Pages | 430-6 |
| PubMed ID | 11327720 | Mgi Jnum | J:69337 |
| Mgi Id | MGI:1934468 | Doi | 10.1006/bbrc.2001.4780 |
| Citation | Henning D, et al. (2001) Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2. Biochem Biophys Res Commun 283(2):430-6 |
| abstractText | Nucleolar protein p40/EBP2 is a proliferation-associated antigen that interacts with Epstein-Barr virus nuclear antigen 1 (EBNA1) to maintain the Epstein-Barr virus (EBV) episomes. The yeast p40/EBP2 functions in the processing of 27S-A into 27S-B ribosomal RNA. The present study reports high evolutionary conservation of the cDNA-derived amino acid sequences of p40/EBP2 from frog, chicken, pig, rat, mouse, bovine, and human. p40/EBP2 is ubiquitously expressed in human tissues. It is highly expressed in myelogenous leukemia K-562 compared to other cell lines tested. The human p40/EBP2 gene is located in chromosome 1 with nine exons and eight introns. The minimal promoter region resides 300 nucleotides upstream of a putative ATG initiation codon preceded by a pyrimidine-rich region. These two regions contain eight Sp1 and four c-Ets-1 putative binding sites. Analysis of the p40/EBP2 gene and its promoter region will facilitate studies on the regulation of its expression in EBV-infected and noninfected cells. |
