| First Author | Ge Y | Year | 2001 |
| Journal | Am J Pathol | Volume | 158 |
| Issue | 1 | Pages | 281-92 |
| PubMed ID | 11141502 | Mgi Jnum | J:67337 |
| Mgi Id | MGI:1930403 | Doi | 10.1016/S0002-9440(10)63967-3 |
| Citation | Ge Y, et al. (2001) Independent influence of strain difference and mi transcription factor on the expression of mouse mast cell chymases. Am J Pathol 158(1):281-92 |
| abstractText | Expression of mouse mast cell protease (mMCP) genes was examined with particular attention to the transactivation effect of mi transcription factor (MITF) and the expression differences between C57BL/6 (B6) and WB strains. We had reported the enhancing effect of MITF on the expression of mMCP-4, -5, and -6 genes in cultured mast cells (CMCs) of B6 strain, and in the present study we demonstrated the enhancing effect on the expression of mMCP-2 and -9 genes as well. The enhancing effect of MITF on the expression of mMCP-2, -4, -5, -6, and -9 genes was also detected in CMCs of the WB strain. The regulation of mMCP-2, -4, and -9 genes was localized to a specific promoter element (CANNTG) which was recognized and bound by MITF and which was conserved between the B6 and WB strains. On the other hand, the expression of mMCP-2, -4, and -9 genes was smaller in CMCs of the B6 strain when compared to their expression in CMCs of the WB strain. Although mMCP-5 is a chymase as mMCP-2, -4, and -9, and genes encoding all of the chymases are located on chromosome 14, the mMCP-5 gene was regulated in a manner distinct from mMCP-2, -4, and -9 genes. |
