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Allele : Tg(Prnp-Immt/SOD1*G93A)7Gmnf transgene insertion 7, Giovanni Manfredi
Primary Identifier  MGI:5575878 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Prnp-Immt/SOD1*G93A)7Gmnf
Strain of Origin  (C57BL/6 x CBA)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  The mito-G93ASOD1 fusion protein contains a mouse mitofilin (Immt) cDNA sequence encoding the first 187 amino acids (including the mitochondrial targeting presequence, MMP cleavage site and transmembrane domain) fused in-frame to the N-terminus of a human Cu,Zn superoxide dismutase cDNA sequence harboring the G93A mutation (SOD1) associated with amyotrophic lateral sclerosis (ALS). The SOD1 start codon was removed and substituted with an in-frame 6 nt DNA linker. This mito-G93ASOD1 sequence was inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at a unique XhoI site in the MoPrP.Xho plasmid vector. The founder line with the highest expression level (founder line 7) was characterized.
  • mutations:
  • Insertion
  • synonyms:
  • mito-SOD1G93A,
  • mito-G93ASOD1,
  • Prp-mito-G93ASOD1,
  • Prp-mito-G93ASOD1,
  • mito-SOD1G93A,
  • mito-G93ASOD1
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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