| Type | MGI:General | Description | nearly all T cells exhibit an activated phenotype in the absence of an overt antigen challenge unlike in wild-type mice following stimulation with anti-CD3 plus anti-CD28 antibodies or phorbol 12-myristate 13-acetate plus ionomycin, a higher percentage of CD4+ T cells produce IL-1 and CD8+ cells produce IL-2 and IFN-gamma compared to in treated wild-type mice T cells acquire the activated phenotype during the double positive to single positive thymocyte transition by a cell-autonomous mechanism |
