| First Author | Liu C | Year | 2011 |
| Journal | Int J Biol Sci | Volume | 7 |
| Issue | 3 | Pages | 347-63 |
| PubMed ID | 21494432 | Mgi Jnum | J:309109 |
| Mgi Id | MGI:6755679 | Doi | 10.7150/ijbs.7.347 |
| Citation | Liu C, et al. (2011) MiR-21 plays an important role in radiation induced carcinogenesis in BALB/c mice by directly targeting the tumor suppressor gene Big-h3. Int J Biol Sci 7(3):347-63 |
| abstractText | Dysregulation of certain microRNAs (miRNAs) in cancer can promote tumorigenesis, metastasis and invasion. However, the functions and targets of only a few mammalian miRNAs are known. In particular, the miRNAs that participates in radiation induced carcinogenesis and the miRNAs that target the tumor suppressor gene Big-h3 remain undefined. Here in this study, using a radiation induced thymic lymphoma model in BALB/c mice, we found that the tumor suppressor gene Big-h3 is down-regulated and miR-21 is up-regulated in radiation induced thymic lymphoma tissue samples. We also found inverse correlations between Big-h3 protein and miR-21 expression level among different tissue samples. Furthermore, our data indicated that miR-21 could directly target Big-h3 in a 3'UTR dependent manner. Finally, we found that miR-21 could be induced by TGFbeta, and miR-21 has both positive and negative effects in regulating TGFbeta signaling. We conclude that miR-21 participates in radiation induced carcinogenesis and it regulates TGFbeta signaling. |
