| Type | MGI:General | Description | hoozygotes develop papillomas on the ear carrying an ear tag suggesting wounding in combination with the mutations causes formation of tumors; tags are attached at 3-5 weeks of age and papillomas develop within 2 months with low incidence papillomas develop on bare skin, typically on the eyelids or footpads of homozygotes with tumor promotion by DMBA or TPA, 50% of homozygotes develop papillomas within 2 weeks of treatment, compared to wild-type treated mice which develop papillomas usually after 10 weeks of treatment number of papillomas increases to 10 per mouse until 7 weeks after onset of gefitinib treatment |
