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Protein Coding Gene : Slc34a3 solute carrier family 34 (sodium phosphate), member 3
Primary Identifier  MGI:2159410 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  142681
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport and sodium ion transmembrane transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit hypercalciuria, hypercalcemia and increased plasma 1,25(OH)2D3 levels but do not develop hypophosphatemia, renal calcification, rickets, or osteomalacia. [provided by MGI curators]
  • synonyms:
  • solute carrier family 34 (sodium phosphate), member 3,
  • AI649385,
  • Npt2c,
  • Slc34a3,
  • MGI:2139031,
  • NPTIIc,
  • expressed sequence AI649385
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Trail: ProteinCodingGene

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