| Primary Identifier | IPR028940 | Type | Family |
| Short Name | TIP5 |
| description | Bromodomain adjacent to zinc finger domain protein 2A (BAZ2A, also known as TIP5)and ATPase SNF2h form the nucleolar remodeling complex (NoRC), which mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing [, ]. TIP5 contains a C-terminal bromodomain, which is found in many chromatin-associated proteins and has been shown to bind to acetylated histone tails. The bromodomain cooperates with an adjacent PHD finger to recruit HDAC1, DNMT1, DNMT3, and SNF2h to rDNA []. |
