| Primary Identifier | MGI:1342286 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14248 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Predicted to act upstream of or within actin cytoskeleton organization. Located in brush border. Is expressed in several structures, including Harderian gland; alimentary system; central nervous system; genitourinary system; and skin. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). PHENOTYPE: Embryos homozygous for a knock-out allele are able to initiate uterine implantation but degenerate rapidly thereafter. Heterozygous mutant mice display enhanced wound healing with increased epithelial migration and improved wound contraction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
