| First Author | Blanco S | Year | 2011 |
| Journal | PLoS Genet | Volume | 7 |
| Issue | 12 | Pages | e1002403 |
| PubMed ID | 22144916 | Mgi Jnum | J:179810 |
| Mgi Id | MGI:5304206 | Doi | 10.1371/journal.pgen.1002403 |
| Citation | Blanco S, et al. (2011) The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet 7(12):e1002403 |
| abstractText | Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate. |
