| First Author | Tiveron MC | Year | 2010 |
| Journal | J Neuroimmunol | Volume | 224 |
| Issue | 1-2 | Pages | 72-9 |
| PubMed ID | 20681075 | Mgi Jnum | J:272319 |
| Mgi Id | MGI:6284313 | Doi | 10.1016/j.jneuroim.2010.05.011 |
| Citation | Tiveron MC, et al. (2010) Expression and function of CXCR7 in the mouse forebrain. J Neuroimmunol 224(1-2):72-9 |
| abstractText | The chemokine CXCL12/CXCR4 signaling system is important for the regulation of neuron migration in the developing forebrain. In particular it is crucial for correct distribution of Cajal-Retzius cells and migration of cortical interneurons. Here we investigated the expression of CXCR7, the second receptor for CXCL12, in comparison to CXCR4. We found that shifts in the expression of both receptors in the above cited cell populations coincide with major changes in their migratory behavior. Furthermore, we demonstrated that postnatally generated olfactory interneuron precursors express CXCR7 but not CXCR4 and that their distribution in the rostral migratory stream is affected by CXCR7 downregulation. This suggests an involvement of CXCR7 in neuronal cell migration and indicates a possible action of CXCR7 independently of CXCR4 as a mediator of CXCL12 signaling. |
