| Primary Identifier | MGI:1337080 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 20602 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables chromatin binding activity; sequence-specific double-stranded DNA binding activity; and transcription corepressor activity. Involved in establishment of skin barrier; gene expression; and protein stabilization. Acts upstream of or within several processes, including forebrain development; positive regulation of protein deacetylation; and type I pneumocyte differentiation. Located in nuclear body. Part of histone deacetylase complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; retina layer; and tooth. Used to study myelofibrosis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). PHENOTYPE: Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
