| Primary Identifier | IPR028318 | Type | Family |
| Short Name | DYRK1A/B_MNB |
| description | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) () phosphorylates serine, threonine and tyrosine residues in proteins such as CRY2, FOXO1 and SIRT1 [, , , ]. It can be activated by tyrosine autophosphorylation [, ]. DYRK1A play a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK1A is a neurogenesis regulator and plays an important role in altered brain development in Down syndrome [, ]. Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B also known as Mirk) also phosphorylates serine, threonine and tyrosine residues, and has been shown to enhance the transcriptional activity of HNF1A and FOXO1 []. Mirk is reported to be an inhibitor of epithelial cell migration [], and appears to mediate carcinoma cell survival in specific environments [].This entry also includes mnb from Drosophila melanogaster. It plays a role in the specific control of proper proliferation of optic lobe neuronal progeny []. |
