Primary Identifier | MGI:1349412 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 26888 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable calcium ion binding activity and mannose binding activity. Predicted to be involved in antifungal innate immune response. Predicted to act upstream of or within adaptive immune response and innate immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased IgG2a, IgG2b and IgG3 levels, increased B cell proliferation, enlarged lymph nodes and degeneration of seminiferous tubules. [provided by MGI curators] |