| First Author | Hook S | Year | 2003 |
| Journal | J Neuroimmunol | Volume | 140 |
| Issue | 1-2 | Pages | 61-8 |
| PubMed ID | 12864972 | Mgi Jnum | J:119036 |
| Mgi Id | MGI:3701037 | Doi | 10.1016/s0165-5728(03)00168-1 |
| Citation | Hook S, et al. (2003) Absence of preproenkephalin increases the threshold for T cell activation. J Neuroimmunol 140(1-2):61-8 |
| abstractText | Certain forms of the neuroendocrine hormone preproenkephalin (PPNK) are produced by T cells, B cells and macrophages. This hormone has been shown to be important in regulating a variety of immune responses; however, the basic mechanisms of this regulation are unknown. Here we examine the ability of CD8 and CD4 PPNK-deficient T lymphocytes to proliferate to antigenic and mitogenic stimuli. We found that lymphocyte activation and proliferation to suboptimal concentrations of both anti-CD3 and antigen was reduced in the absence of PPNK. Proliferation could be rescued by increasing antigen or by co-incubation of PPNK-deficient cells with wild-type cells. These data confirm the importance of neuroendocrine hormones such as PPNK in T cell activation and proliferation and provides a potential mechanism for the regulation of T cell responses by PPNK or its peptide derivatives. |
