| First Author | Collins BJ | Year | 2004 |
| Journal | Semin Cancer Biol | Volume | 14 |
| Issue | 5 | Pages | 357-64 |
| PubMed ID | 15288261 | Mgi Jnum | J:91818 |
| Mgi Id | MGI:3050901 | Doi | 10.1016/j.semcancer.2004.04.015 |
| Citation | Collins BJ, et al. (2004) Notch in lung development and lung cancer. Semin Cancer Biol 14(5):357-64 |
| abstractText | Although data regarding the role of the Notch pathway in human lung cancer are still limited, fetal lung developmental studies suggest that Notch signaling plays a critical role in regulating airway epithelial development. The moderate hypotrophic phenotype of lungs from animals bearing a Hes1 mutation, and the expression of Notch components in the distal lung bud during branching morphogenesis, together suggest that Notch may play a role in normal lung growth, especially in Clara cell precursors. Non-small cell lung cancers, including adenocarcinoma, appear to actively utilize this conserved developmental pathway. Pharmacologic inhibition of the Notch pathway is a potential experimental approach to lung cancer treatment. |
