|  Help  |  About  |  Contact Us

Protein Coding Gene : Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

Primary Identifier  MGI:1891259 Organism  mouse, laboratory
Chromosome  3 NCBI Gene Number  79235
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables phosphatidylcholine-retinol O-acyltransferase activity. Involved in retinol metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and vitamin A metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including extraembryonic component; gut; midbrain; reproductive system; and retina. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase).
PHENOTYPE: Mice homozygous for disruptions in this gene exhibit retinol homeostasis abnormalities and are more susceptible to vitamin A deficiency or display impaired vision associated with abnormal retinol metabolism. Males have testicular hypoplasia/atrophy and reduced mature sperm counts. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI449251,
  • Lrat,
  • 1300010A18Rik,
  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase),
  • MGI:2139712,
  • MGI:1919009,
  • AI449251,
  • RIKEN cDNA 1300010A18 gene

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

2 Driver For