| First Author | Xiong YS | Year | 2015 |
| Journal | Aging Cell | Volume | 14 |
| Issue | 5 | Pages | 867-77 |
| PubMed ID | 26111662 | Mgi Jnum | J:227579 |
| Mgi Id | MGI:5701583 | Doi | 10.1111/acel.12366 |
| Citation | Xiong YS, et al. (2015) Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. Aging Cell 14(5):867-77 |
| abstractText | The two estrogen receptors (ERs), ERalpha and ERbeta, mediate the diverse biological functions of estradiol. Opposite effects of ERalpha and ERbeta have been found in estrogen-induced cancer cell proliferation and differentiation as well as in memory-related tasks. However, whether these opposite effects are implicated in the pathogenesis of Alzheimer's disease (AD) remains unclear. Here, we find that ERalpha and ERbeta play contrasting roles in regulating tau phosphorylation, which is a pathological hallmark of AD. ERalpha increases the expression of miR-218 to suppress the protein levels of its specific target, protein tyrosine phosphatase alpha (PTPalpha). The downregulation of PTPalpha results in the abnormal tyrosine hyperphosphorylation of glycogen synthase kinase-3beta (resulting in activation) and protein phosphatase 2A (resulting in inactivation), the major tau kinase and phosphatase. Suppressing the increased expression of miR-218 inhibits the ERalpha-induced tau hyperphosphorylation as well as the PTPalpha decline. In contrast, ERbeta inhibits tau phosphorylation by limiting miR-218 levels and restoring the miR-218 levels antagonized the attenuation of tau phosphorylation by ERbeta. These data reveal for the first time opposing roles for ERalpha and ERbeta in AD pathogenesis and suggest potential therapeutic targets for AD. |
