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Protein Coding Gene : Dock1 dedicator of cytokinesis 1
Primary Identifier  MGI:2429765 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  330662
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including dermomyotome; genitourinary system; heart; hemolymphoid system gland; and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1).
PHENOTYPE: Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate. [provided by MGI curators]
  • synonyms:
  • 9130006G06Rik,
  • D630004B07Rik,
  • Dock1,
  • RIKEN cDNA D630004B07 gene,
  • Bench to Bassinet Program (B2B/CVDC), mutation 3190Cecilia Lo,
  • RIKEN cDNA 9130006G06 gene,
  • MGI:2442765,
  • expressed sequence AI854900,
  • Dock180,
  • Mutant line 3190,
  • MGI:2142074,
  • AI854900,
  • MGI:1918821,
  • MGI:5618854,
  • dedicator of cytokinesis 1,
  • b2b3190Clo
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