| First Author | Ikeda Y | Year | 1995 |
| Journal | Mol Endocrinol | Volume | 9 |
| Issue | 4 | Pages | 478-86 |
| PubMed ID | 7659091 | Mgi Jnum | J:112439 |
| Mgi Id | MGI:3656337 | Doi | 10.1210/mend.9.4.7659091 |
| Citation | Ikeda Y, et al. (1995) The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 9(4):478-86 |
| abstractText | The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Mullerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction. |
