| Primary Identifier | IPR020446 | Type | Family |
| Short Name | NTRK3 |
| description | Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. NTRK3 (also termed TrkC) is a high-affinity receptor for neurotrophin-3 (NT-3). The receptor is widely expressed in the developing nervous system, and is also found in many non-neuronal tissues []. In addition to roles in peripheral nerve cell myelination, mediating the inhibitory effects of NT-3 on this process []. |
