| Primary Identifier | IPR018574 | Type | Family |
| Short Name | Structure-sp_endonuc_su_Slx4 |
| description | The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 is a regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination [, ]. The SLX1-SLX4 complex has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs) [, ]. Defects in SLX4 are the cause of Fanconi anemia complementation group P (FANCP), which is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia [, ]. |
