| First Author | Henkemeyer M | Year | 1995 |
| Journal | Nature | Volume | 377 |
| Issue | 6551 | Pages | 695-701 |
| PubMed ID | 7477259 | Mgi Jnum | J:29825 |
| Mgi Id | MGI:77341 | Doi | 10.1038/377695a0 |
| Citation | Henkemeyer M, et al. (1995) Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 377(6551):695-701 |
| abstractText | The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutati ons in the Gap and Nf1 genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development. |
