| Primary Identifier | IPR036818 | Type | Homologous_superfamily |
| Short Name | AIDA_N_sf |
| description | This entry represents the N-terminal domain of the axin interactor, dorsalization-associated protein (AIDA) superfamily []. AIDA acts as a ventralizing factor during embryogenesis. It inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling []. The core structure of the AIDA N-terminal domain consists of four helices arranged in a close or partly open bundle fold with left-handed twist going up-and-down. |
