| Primary Identifier | IPR028460 | Type | Family |
| Short Name | Tbh/DBH |
| description | This entry includes tyramine beta-hydroxylases from invertebrates and dopamine beta-hydroxylases from mammals. Tyramine beta-hydroxylase (TBH) converts tyramine into octopamine, a neurotransmitter involved in pharyngeal pumping and egg laying in Caenorhabditis elegans []and in ovulation and locomotion in Drosophila [, , ]. It is evolutionarily related and remarkably similar to mammalian dopamine beta-hydroxylase [].Dopamine beta-hydroxylases (DBH) converts dopamine to noradrenaline (norepinephrine), a key neurotransmitter of the central and peripheral nervous systems [, ]. DBH is a copper-containing oxygenase consisting of four identical subunits. Mutations in DBH gene cause the dopamine beta-hydroxylase deficiency (DBH deficiency), which is characterised by profound deficits in autonomic and cardiovascular function []. |
