| First Author | Anz D | Year | 2015 |
| Journal | Cancer Res | Volume | 75 |
| Issue | 21 | Pages | 4483-93 |
| PubMed ID | 26432403 | Mgi Jnum | J:226771 |
| Mgi Id | MGI:5698555 | Doi | 10.1158/0008-5472.CAN-14-3499 |
| Citation | Anz D, et al. (2015) Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression. Cancer Res 75(21):4483-93 |
| abstractText | The chemokine CCL22 is abundantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulatory T cells (Treg), an important subset of immunosuppressive and tumor-promoting lymphocytes. In this study, we offer evidence for a generalized strategy to blunt Treg activity that can limit immune escape and promote tumor rejection. Activation of innate immunity with Toll-like receptor (TLR) or RIG-I-like receptor (RLR) ligands prevented accumulation of Treg in tumors by blocking their immigration. Mechanistic investigations indicated that Treg blockade was a consequence of reduced intratumoral CCL22 levels caused by type I IFN. Notably, stable expression of CCL22 abrogated the antitumor effects of treatment with RLR or TLR ligands. Taken together, our findings argue that type I IFN blocks the Treg-attracting chemokine CCL22 and thus helps limit the recruitment of Treg to tumors, a finding with implications for cancer immunotherapy. Cancer Res; 75(21); 4483-93. (c)2015 AACR. |
