| First Author | Su YW | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 2 | Pages | 295-305 |
| PubMed ID | 12932362 | Mgi Jnum | J:85187 |
| Mgi Id | MGI:2673057 | Doi | 10.1016/s1074-7613(03)00202-4 |
| Citation | Su YW, et al. (2003) LAT links the pre-BCR to calcium signaling. Immunity 19(2):295-305 |
| abstractText | SLP-65(-/-) mice display a partial block at the pre-B cell stage of development. Here, we show that LAT is required for the differentiation of SLP-65(-/-) pre-B cells. We show that LAT and SLP-76 are recruited to the pre-BCR and associated with Ig-alpha upon pre-BCR engagement, whereas LAT interaction with SLP-76 is already detected in untreated pre-B cells. Reconstitution of LAT or SLP-65 expression in SLP-65/LAT(-/-) pre-B cells restored their calcium (Ca2+) mobilization capacity, led to downregulation of surface pre-BCR, and induced differentiation to BCR+ cells. Together, our results suggest that the adaptor proteins LAT and SLP-76 are involved in pre-BCR signaling, thereby rescuing arrested murine SLP-65(-/-) pre-B cells. |
