| First Author | Bourdon JC | Year | 2002 |
| Journal | J Cell Biol | Volume | 158 |
| Issue | 2 | Pages | 235-46 |
| PubMed ID | 12135983 | Mgi Jnum | J:78076 |
| Mgi Id | MGI:2183272 | Doi | 10.1083/jcb.200203006 |
| Citation | Bourdon JC, et al. (2002) Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J Cell Biol 158(2):235-46 |
| abstractText | p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after gamma-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis. |
