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Publication : Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).

First Author  Baba T Year  1993
Journal  FEBS Lett Volume  322
Issue  2 Pages  89-94
PubMed ID  8482392 Mgi Jnum  J:4982
Mgi Id  MGI:53461 Doi  10.1016/0014-5793(93)81544-a
Citation  Baba T, et al. (1993) Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett 322(2):89-94
abstractText  Mouse genomic clones encoding the epithelin/granulin gene and its 5'- and 3'-flanking regions have been isolated and sequenced. This gene was found to be a single-copy gene, and contained 13 exons interrupted by 12 introns. Eight out of the 12 introns are classified as phase 0, and are located within the central part of each of the tandem repeats in the amino acid sequence of the epithelin/granulin precursor. The first intron is unique because of the interruption of the 5'-untranslated region and its fairly large size (approximately 2.4 kbp). Consensus sequences for several of the potential regulatory elements are present in the 5'-flanking sequence, including a common CCAAT sequence.
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