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Publication : Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate.

First Author  Tan SH Year  2015
Journal  Cancer Cell Volume  28
Issue  6 Pages  683-685
PubMed ID  26678334 Mgi Jnum  J:227327
Mgi Id  MGI:5700243 Doi  10.1016/j.ccell.2015.11.004
Citation  Tan SH, et al. (2015) Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate. Cancer Cell 28(6):683-5
abstractText  Wnt signaling drives colorectal cancer stem cells, but effective therapeutics targeting these cells and their signaling pathways are lacking. In this issue of Cancer Cell, Ordonez-Moran and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.
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