| First Author | Kamiyoshi A | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 343 |
| Issue | 1 | Pages | 152-8 |
| PubMed ID | 16530166 | Mgi Jnum | J:107481 |
| Mgi Id | MGI:3621311 | Doi | 10.1016/j.bbrc.2006.02.132 |
| Citation | Kamiyoshi A, et al. (2006) Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice. Biochem Biophys Res Commun 343(1):152-8 |
| abstractText | To evaluate hepatoprotective effect of alpha-calcitonin gene-related peptide (alphaCGRP), we compared the susceptibilities of alphaCGRP-/- and wild-type mice to concanavalin A (Con A)-induced hepatitis. Twelve hours after Con A administration, serum transaminases were markedly higher in alphaCGRP-/- than wild-type mice, and much more extensive TUNEL-positive lesions and DNA fragmentation were detected in the livers of alphaCGRP-/- mice. Notably, expression of IL-6 was selectively diminished in alphaCGRP-/- mice, suggesting that induction of IL-6 during acute inflammatory responses is blunted in alphaCGRP-/- mice. In addition, primary cultured alphaCGRP-/- hepatocytes were more susceptible to IFN-gamma-induced cell death than hepatocytes from wild-type mice. Administration of exogenous alphaCGRP reduced the incidence of apoptosis among hepatocytes and endothelial cells. It thus appears that alphaCGRP exerts a hepatoprotective effect by modulating cytokine expression and preventing apoptosis. |
