| First Author | Echard A | Year | 1998 |
| Journal | Science | Volume | 279 |
| Issue | 5350 | Pages | 580-5 |
| PubMed ID | 9438855 | Mgi Jnum | J:45570 |
| Mgi Id | MGI:1195621 | Doi | 10.1126/science.279.5350.580 |
| Citation | Echard A, et al. (1998) Interaction of a Golgi-associated kinesin-like protein with Rab6. Science 279(5350):580-5 |
| abstractText | Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic. |
