| First Author | Wang CX | Year | 2000 |
| Journal | Blood | Volume | 96 |
| Issue | 1 | Pages | 259-63 |
| PubMed ID | 10891459 | Mgi Jnum | J:63387 |
| Mgi Id | MGI:1860838 | Doi | 10.1182/blood.v96.1.259.013k36_259_263 |
| Citation | Wang CX, et al. (2000) Overexpression of murine fizzy-related (fzr) increases natural killer cell-mediated cell death and suppresses tumor growth. Blood 96(1):259-63 |
| abstractText | Fizzy-related (fzr) is a recently identified 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. In this study, the murine homologue of fzr was isolated by suppression subtractive hybridization as a gene with decreased expression during malignant progression of a murine B-lymphoma cell line. Retroviral overexpression of fzr in B-lymphoma cells reduced tumor formation. Those tumors that did arise had diminished or extinguished retroviral Fzr. Surprisingly, fzr overexpression dramatically increased B-lymphoma cell susceptibility to natural killer cell (NK) cytotoxicity, a host-resistant mechanism for tumor formation in this model system. These findings implicate fzr as a new category of genes suppressing B-cell tumorigenesis and suggest a novel role for fzr in the target cell interaction with NK cells. |
