Primary Identifier | MGI:101947 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 11991 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in mRNA transcription by RNA polymerase II; positive regulation of telomere capping; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of mRNA stability. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). PHENOTYPE: Homozygous mutation of this gene results in fetal growth retardation and decreased body weight. Mice show increased susceptibility to bacterial infection and endotoxin shock. [provided by MGI curators] |