| First Author | Larsson NG | Year | 1996 |
| Journal | Nat Genet | Volume | 13 |
| Issue | 3 | Pages | 296-302 |
| PubMed ID | 8673128 | Mgi Jnum | J:33733 |
| Mgi Id | MGI:81210 | Doi | 10.1038/ng0796-296 |
| Citation | Larsson NG, et al. (1996) A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet 13(3):296-302 |
| abstractText | Mitochondrial transcription factor A (mtTFA) is a key regulator of mammalian mitochondrial DNA transcription. We report here that a testis-specific isoform of mouse mtTFA lacks the mitochondrial targeting sequence and is present in the nucleus of spermatocytes and elongating spermatids, thus representing the first reported mammalian gene encoding protein isoforms targeted for the mitochondria or the nucleus. The presence of the mitochondrial transcriptional activator in the nucleus raises the possibility of a role for this protein in both genetic systems. Mutations in the nuclear mtTFA gene may therefore exhibit phenotypic consequences due to altered function in either or both genetic compartments. |
