| First Author | Smith C | Year | 2008 |
| Journal | Eur J Immunol | Volume | 38 |
| Issue | 7 | Pages | 1857-66 |
| PubMed ID | 18506880 | Mgi Jnum | J:137312 |
| Mgi Id | MGI:3798748 | Doi | 10.1002/eji.200737933 |
| Citation | Smith C, et al. (2008) Generating functional CD8(+) T cell memory response under transient CD4(+) T cell deficiency: Implications for vaccination of immunocompromised individuals. Eur J Immunol 38(7):1857-66 |
| abstractText | Studies based on either MHC class II-knockout or CD4(+) T cell-depleted murine models have demonstrated a critical role for CD4(+) T cells in the generation of CD8(+) T cell memory. However, it is difficult to extend these findings to immunocompromised humans where a complete loss of CD4(+) T cells is rarely observed. Here, we have developed a model setting, which allows studies on the generation of CD8(+) T cell memory responses in a transient CD4(+) T cell-deficient setting similar to that seen in immunocompromised patients. Immunisation with an adenoviral vaccine under transient helpless or help-deficient conditions showed varying degrees of impact on the priming of CD8(+) T cell responses. Antigen-specific T cells generated under normal CD4(+) T cell help and transient help-deficient conditions showed similar effector phenotype and were capable of proliferation upon secondary antigen encounter. Most importantly, in spite of CD4(+) T cell deficiency, the long-term CD8(+) T cell memory response remained functionally stable and showed comparable cytotoxic effector function as seen in CD8(+) T cells generated with normal CD4(+) T cell numbers. These findings provide evidence that in spite of partially impaired activation of a primary CD8(+) T cell response, a fully functional and stable memory CTL response can be induced under conditions of severe transient CD4(+) T cell deficiency. |
