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Publication : Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems.

First Author  Williams NS Year  1998
Journal  Immunol Rev Volume  165
Pages  47-61 PubMed ID  9850851
Mgi Jnum  J:51085 Mgi Id  MGI:1314574
Doi  10.1111/j.1600-065x.1998.tb01229.x Citation  Williams NS, et al. (1998) Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems. Immunol Rev 165:47-61
abstractText  In the last few years, the routine development of knockout and transgenic mice and the ease with which rare progenitor populations can be isolated from hematopoietic organs and cultured in vitro has facilitated significant advances in understanding the lineage and development of natural killer (NK) cells. Fluorescence-activated cell sorter analyses have identified a common lymphoid progenitor capable of giving rise to NK, T, and B cells, confirming the lymphoid origin of NK cells. Knockout and transgenic mouse models have pointed to an absolutely critical role for signals sent through the interleukin (IL)- 2/15 receptor beta (CD122) chain and common gamma (gamma c) chain for NK development. Such signals are likely relayed inside the cell by the tyrosine kinase Jak3, which associates with gamma c. Recently developed IL-15 and IL-15 receptor alpha knockout mice have pinpointed IL-15 as the mediator of this signal. Other mouse models have indicated an unexpected role for flt3 ligand in early NK-cell development as well as minor roles for stem cell factor and IL-7 in expanding NK-cell progenitor numbers. Finally, in vitro culture systems have proven useful in identifying the point in NK development at which each of these signals is critical.
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