| First Author | Prévost CL | Year | 1975 |
| Journal | J Immunol | Volume | 115 |
| Issue | 3 | Pages | 640-3 |
| PubMed ID | 168262 | Mgi Jnum | J:23509 |
| Mgi Id | MGI:71261 | Doi | 10.4049/jimmunol.115.3.640 |
| Citation | Le Prevost C, et al. (1975) Immunopathology of mouse hepatitis virus type 3 infection. III. Clinical and virologic observation of a persistent viral infection. J Immunol 115:640-3 |
| abstractText | Three types of viral sensitivity were observed in various mouse strains upon MHV3 infection: resistance, full susceptibility, and semisusceptibility. In the latter type, seen in several inbred strains including C3H, approximately 50% of the adult injected animals resisted to the acute disease. Most of the surviving mice, however, developed a chronic disease with a wasting syndrome and occurrence of paralysis. The chronic period of the disease was characterized by a persistent viral infection, since MHV3 virus was recovered from brain, liver, spleen, and lymph nodes throughout the evolution in most of the animals. In addition, a correlation was observed between the clinical evolution and the titer of virus tested 4 days after infection. |
