| First Author | van Lohuizen M | Year | 1991 |
| Journal | Nature | Volume | 353 |
| Issue | 6342 | Pages | 353-5 |
| PubMed ID | 1922340 | Mgi Jnum | J:12667 |
| Mgi Id | MGI:60904 | Doi | 10.1038/353353a0 |
| Citation | van Lohuizen M, et al. (1991) Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353(6342):353-5 |
| abstractText | The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse protein Mel-18. Here we report on the cloning and characterization of a homologous gene (D-bmi) from Drosophila melanogaster. Our analysis indicates that distinct domains of the mouse Bmi-1 protein, including the putative zinc-finger motif, are highly conserved within the much larger D-Bmi protein. Chromosomal localization and sequence comparison reveal that D-bmi is identical to Posterior Sex Combs (Psc) and indicate that the conserved domains between mouse bmi and Psc are also conserved within Suppressor-2 of Zeste (Su(z)2). |
