| Primary Identifier | MGI:3697064 | Allele Type | Transgenic |
| Attribute String | Reporter | Gene | Tg(BAT-lacZ)3Picc |
| Strain of Origin | (C57BL/6 x DBA/2)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | This is one of three "BAT-gal" transgenic lines generated, which the authors state exhibitied "qualitatively identical expression patterns, although quantitative differences could be observed." |
| molecularNote | Mice with this transgene express nuclear beta-galactosidase under control of the beta-catenin-activated transgene (BAT) promoter. This promoter consists of a DNA fragment extending 0.13 kb upstream from the translation start site of the novel protein containing homeodomain (siamois) gene of Xenopus laevis, which contains the (beta-catenin non-responsive) minimal promoter of this natively beta-catenin activated gene, downstream of seven synthetic lymphoid enhancer factor/T-cell factor- (LEF/TCF-) binding sites that effectively restore the promoter's beta-catenin responsiveness. The transgene does not segregate randomly with respect to the Jup locus indicating that the transgene insertion site is genetically linked to Jup. |
