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Publication : Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains.

First Author  Yokoyama M Year  1997
Journal  Biochim Biophys Acta Volume  1353
Issue  1 Pages  13-7
PubMed ID  9256059 Mgi Jnum  J:41609
Mgi Id  MGI:894139 Doi  10.1016/s0167-4781(97)00074-2
Citation  Yokoyama M, et al. (1997) Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Biochim Biophys Acta 1353(1):13-7
abstractText  We have isolated a human cDNA clone representing a novel human gene. The predicted 683-amino-acid protein, designated FPM315, contains nine C2H2-type zinc finger motifs and two regions homologous to the LeR domain, a finger-associated structural domain, and the A element of the Kruppel-associated box (KRAB) domain involved in transcriptional repression. The FPM315 mRNAs were expressed in all human tissues so far examined. A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes.
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