| First Author | Lai M | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12207 | PubMed ID | 27481093 |
| Mgi Jnum | J:236920 | Mgi Id | MGI:5810223 |
| Doi | 10.1038/ncomms12207 | Citation | Lai M, et al. (2016) Regulation of B-cell development and tolerance by different members of the miR-17 approximately 92 family microRNAs. Nat Commun 7:12207 |
| abstractText | The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17 approximately 92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways. |
