| First Author | Chien CL | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 13 | Pages | 2883-90 |
| PubMed ID | 20466003 | Mgi Jnum | J:161317 |
| Mgi Id | MGI:4457984 | Doi | 10.1016/j.febslet.2010.05.004 |
| Citation | Chien CL, et al. (2010) Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6). FEBS Lett 584(13):2883-90 |
| abstractText | Adenylyl cyclase (AC) type VI (AC6) is a calcium-inhibitable enzyme which produces cAMP upon stimulation. Herein, we characterized the specific role of AC6 in the kidneys using two AC6-knockout mouse lines. Immunohistochemical staining revealed that AC6 exists in the tubular parts of the nephron and collecting duct. Activities of AC evoked by forskolin or a selective agonist of the V2 vasopressin receptor were lower in the kidneys of AC6-null mice compared to those of wildtype mice. Results of a metabolic cage assay and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) showed for the first time that AC6 plays a critical role in regulating water homeostasis. |
